Research Article
Correlation Between Serum Level of TSH Receptor Antibody and Severity of Graves’ Orbitopathy
Karim Nasr El Din Abbas,
Sheriff Elwan,
Radwa Elsherif*,
Mina Nesim,
Mahmoud Elsamkary
Issue:
Volume 10, Issue 3, September 2025
Pages:
42-49
Received:
14 May 2025
Accepted:
3 June 2025
Published:
21 July 2025
Abstract: Purpose: evaluating relationship between serum level of TSH Receptor Antibody (TRAb) and severity of Graves’ ophthalmopathy (GO). Methods: prospective interventional follow up study included 35 newly diagnosed untreated patients with GO was carried at Ain Shams University Hospital, Cairo. patients were subjected to full ophthalmological examination, measuring proptosis degree by Hertel’s Exophthalmometer, measuring TRAb serum level. patients were classified according to clinical activity score into 2 groups: Inactive [CAS < 3]: 23 patients received only antithyroid therapy and Active [CAS ≥ 3]: 12 patients received intravenous methylprednisolone at a dose of 0.5gm for 6 weeks, injected weekly. 6 weeks after treatment severity of (GO), proptosis, and TRAb serum level were reassessed. Results: study found the mean CAS was 2.11±1.13, the mean proptosis measured (23.26 ±3.19) and (22.42 ± 3.27) in right and left eye respectively while mean of TRAb was 11.19 ±6.45. After 6 weeks of treatment, CAS was regressed significantly in relation to TRAb level as TRAb measurement decreased by -62.7%, -14.06% in group II and group I respectively while proptosis measurement of right and left eyes in group II significantly decreased, with mean changes of -10.3% and -10.7%, respectively. And, in group I (-4.5% and -3.8%) in right and left eyes respectively, but not significant to TRAb level. Conclusion TRAb level can be used as monitor to activity of Grave’s Ophthalmopathy (GO) and in follow up but not directly related to proptosis degree.
Abstract: Purpose: evaluating relationship between serum level of TSH Receptor Antibody (TRAb) and severity of Graves’ ophthalmopathy (GO). Methods: prospective interventional follow up study included 35 newly diagnosed untreated patients with GO was carried at Ain Shams University Hospital, Cairo. patients were subjected to full ophthalmological examination...
Show More
Case Report
Monitoring the Evolution of Stage IV-A Retinopathy of Prematurity Using Retinal Imaging: A Case Series
Issue:
Volume 10, Issue 3, September 2025
Pages:
50-55
Received:
7 August 2025
Accepted:
20 August 2025
Published:
11 September 2025
DOI:
10.11648/j.ijovs.20251003.12
Downloads:
Views:
Abstract: Amidst the growing Retinopathy of Prematurity (RoP) crisis in India, tele-screening has assumed an important role, enabling RoP practitioners to screen a large number of babies without the need to travel everywhere. Though Binocular Indirect Ophthalmoscopic (BIO) examination is the current gold-standard for RoP screening, RoP drawings have not been scientifically evaluated for accuracy. There is significant inter-observer variability in this method of documentation. Digital fundus imaging is reproducible, quick and additionally can help to detect minute changes in the disease state which are not so obvious on Indirect Ophthalmoscopy examination. Digital Fundus Imaging can also help in parent counselling and medicolegal documentation. We present three cases of peri-papillary volcano-type tractional retinal detachment which were serially monitored using fundus imaging. The 3Nethra Neo Fundus Camera by Forus Health, Bengaluru, India was utilized for screening these infants. It employs a light-weight, hand-held probe with an Light Emitting Diode (LED) light source for capturing images. Using this fundus camera, we monitored the evolution of these three cases and were able to observe a clear regression of the disease after RoP Laser. Surgical intervention was successfully avoided and these babies have remained stable. These results are all the more gratifying when we consider the surgical burden of RoP in India.
Abstract: Amidst the growing Retinopathy of Prematurity (RoP) crisis in India, tele-screening has assumed an important role, enabling RoP practitioners to screen a large number of babies without the need to travel everywhere. Though Binocular Indirect Ophthalmoscopic (BIO) examination is the current gold-standard for RoP screening, RoP drawings have not been...
Show More
,
Anand Subramanyam*
